Case Conversation: Alternative routes for tranexamic acid treatment in obstetric bleeding (WOMAN-PharmacoTXA trial)

July 26, 2023

This is a recorded version of the journal club program, Case Conversation: Alternative routes for tranexamic acid treatment in obstetric bleeding (WOMAN-PharmacoTXA trial) that was presented live on July 26, 2023.  Please scroll all the way down this page to view the archived program.

Webinar Date: 7/26/2023
Estimated Time to complete: 1 hour
Format: Archived Webinar
Target Audience: This activity is designed for women’s healthcare professionals, including obstetricians, gynecologists, maternal-fetal medicine specialists, pediatric/adolescent gynecologists, advance practice providers, and nurses specializing in women’s health are the primary target audience to ensure optimal comprehensive care. Researchers and scientists can additionally benefit from this activity.

Program Description:
In 2017, the World Health Organization (WHO) strongly recommended early treatment with intravenous (IV) tranexamic acid (TXA) for women with postpartum hemorrhage (PPH) after vaginal birth or cesarean section. There are many reasons as to why access to IV-TXA may be a barrier, delaying timely and life-saving treatment. This study explores the different routes of TXA administration in women at increased risk of PPH following birth by cesarean section. Researchers investigated the efficacy of therapy through different routes of administration (IV, intramuscular (IM), and oral) and the concentrations over time with population pharmacokinetics.

This case conversation will address the following learning objectives:
1. Explain differences between intravenous (IV), intramuscular (IM) and oral tranexamic acid for prevention of postpartum hemorrhage at the time of delivery.
2. Discuss the safety of using tranexamic acid for the mother and neonate in the peripartum period.
3. Explore future studies that will evaluate efficacy and safety of tranexamic acid at cesarean and vaginal delivery for postpartum hemorrhage prevention.

Homa K. Ahmadzia, MD, MPH

Associate Professor
Division of Maternal-Fetal Medicine
Department of Obstetrics & Gynecology
The George Washington University

Monica Arribas, PhD
Research Fellow and Senior Trial Manager
Faculty of Epidemiology and Public Health
London School Of Hygiene and Tropical Medicine

Jamil Kazma, MD
Obstetrics and Gynecology Resident Physician
School of Medicine and Health Sciences
The George Washington University

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