New data collected from 451 women (2-69 years), presumed to be hemophilia carriers, who were enrolled in the Universal Data collection (UDC) System, finds that female hemophilia carriers (of all ages) "had evidence of joint abnormalities as early as the pre-teen years regardless of severity of hemophilia symptoms." The results also suggested that joint bleeding might be occurring before the female reaches adolescence.
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Sidonio RF, Mili FD, Li T, Miller CH, Hooper WC, DeBaun MR, Soucie MJ, and the Hemophilia Treatment Centers Network. Females with FVIII and FIX deficiency have reduced joint range of motion. American Journal of Hematology 2014 89(8):831-836.