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Thank you for registering and pre-test questions

Thank you registering for FWGBD's webinar: Women and Bleeding: Challenges of Hemophilia Carriage, VWD, and Other Rare Bleeding Disorders

To complete your registration, we ask that you please complete the following 10 pre-test questions. Your answers will be kept confidential.

After registering, you will receive a confirmation e-mail containing information about joining the webinar.

Thank you.

Which of the following constitutes Heavy Menstrual Bleeding?

Clots > 1 inch diameter Low ferritin Flooding – changing pad/tampon hourly Blood loss of >80 ml per menstrual cycle lasting longer than 7 days All of the above

Which of the following can make heavy menstrual bleeding worse?

Antifibrinolytics Factor concentrates Platelet Transfusions Aspirin Oral contraceptives

The most common types of bleeding disorders associated with heavy menstrual blood loss are:

von Willebrand Disease Factor XII deficiency Hemophilia carriers Platelet function disorders A and D

17-year-old female presents with menorrhagia and a history of epistaxis. The patient’s brother and mother have a history of gum bleeding. Laboratory results show that Complete Blood Count, Prothrombin time (PT), activated Partial thromboplastin time (aPTT), fibrinogen and platelet aggregation tests were normal. Her FVIII assay was 32% (Normal 50-150%), Von Willebrand Antigen 12% (normal 50-150 %), and Ristocetin cofactor assay 26% (normal 50-150%). Based on the laboratory results, which of the following is the patient most likely to have?

Immune thrombocytopenia Glanzmann’s Thrombasthenia von Willebrand Disease Aspirin effect FVII deficiency

You recently were asked to evaluate a 21-year-old young woman with a family history of Factor VII deficiency, prior to wisdom tooth extraction. Which of the following symptoms would you elicit in your history that would most likely be associated with FVII deficiency:

Menorrhagia Easy bruisability Epistaxis Excessive bleeding from wounds All of the above

A 9-year-old girl, who is a recent immigrant from India with Hx of easy bruising, Her Mother stated that at birth, it took a long time for her umbilicus to stop oozing. The parents were related, and the mother had excessive bleeding following delivery and a cousin who had suffered intracranial hemorrhage as a baby. You obtain a lab test that shows: APTT 35 sec (normal 35-40 seconds), PT 10 sec (normal 10-12 seconds), and platelet count was 156,000/mm3. Which of the following is the most likely diagnosis?

Hemophilia A or B carrier Factor XIII deficiency Disseminated intravascular coagulopathy Vitamin K deficiency Hereditary hemorrhagic telangiectasia

When is the optimal timing of hemophilia carrier testing?

At birth Prenatally via Chorionic Villus Sampling Prior to surgery or menstruation Prior to conception or during pregnancy planning C and D

Which of the following testing is first recommended to screen for hemophilia carriage?

FVIII antigen aPTT FVIII activity Thrombin time Inversion 22 mutation in cDNA

In this hemophilia A carrier, you checked her FVIII activity and it was 125% at the end of her third trimester. Which of the following modes of delivery would you recommend?

Vaginal delivery Vaginal delivery with vacuum extraction to avoid C-section Planned C-section with regional anesthesia Planned C-section with general anesthesia A or C

Which of the following is not an obligate hemophilia carrier?

Daughter of a male with hemophilia Mother of a male with hemophilia and no family history of a bleeding disorder Sister of a male with hemophilia and a known uncle with hemophilia Mother of a male with hemophilia with reported history of maternal grandfather with hemophilia All of the above

What is 2+2?*

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