This article outlines factors that can affect coagulation during laboratory testing. Factors discussed include exercise, mental stress, hormone influence, circadian variation, posture and dietary influences and smoking. Guidelines are offered to control preanalytical conditions in patients undergoing coagulation testing. Because of the significance of VWD and other inherited disorders of hemostasis resulting in bleeding symptoms in women, these effects should be considered in laboratory testing.

Blomback M, Konkle BA, Manco-Johnson MJ, Bremme K, Hellgren M, Kaaja R. ISTH SSC Subcommittee on Women’s Health Issues. Preanalytical conditions that affect coagulation testing, including hormonal status and therapy. J Thromb Haemost. 2007; 5:855-858. 

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