The Foundation for Women & Girls with Blood Disorders is proud to announce its upcoming Friday Satellite Symposium preceding the 60th American Society of Hematology (ASH) Annual Meeting and Exposition:

Evaluation and Treatment of Complement-Mediated Blood Disorders in Women of Childbearing Age - November 30, 2018 - 7am-11am, Grand Hyatt - Room Grand D, San Diego, CA

Reserve your space early. Register HERE.

This symposium brings together leading experts in the field to review the complement physiology with an emphasis on the intersection of complement, coagulation, and diseases affecting women of reproductive age. The complement system is an under-appreciated pathogenic mechanism for thrombotic and inflammatory disorders, with significant cross-talk between complement, coagulation, and fibrinolytic systems. Several hematological diseases including atypical hemolytic uremic syndrome (aHUS), paroxysmal nocturnal hemoglobinuria (PNH), antiphospholipid syndrome (APS), HELLP (Hemolysis, Elevated Liver enzymes, and Low Platelet count) syndrome and even thrombotic thrombocytopenic purpura (TTP) are, or may be, complement-mediated diseases. Given the rarity of these syndromes, hematologists, and obstetricians, alike, have a limited understanding of complement’s role in these diseases or emerging therapies directed at complement pathways. The faculty will provide a comprehensive review of these topics, as well as current diagnostic and treatment strategies that can lead to improved care for women of childbearing age, and then will address issues and questions from the audience. 

Learning Objectives:

At the conclusion of this activity, participants should be able to:

  • Describe components of complement and complement regulatory proteins
  • Identify the role of complement in the thrombotic spectrum of disorders
  • Recognize and manage the range of complications related to uncontrolled complement activation in pregnant women with aHUS  
  • Recognize the role of anticoagulation during pregnancy and the postpartum period in women with PNH 
  • Appropriately apply complement inhibitory therapy during pregnancy and the postpartum period in women with PNH
  • Explain the diagnostic challenges due to the heterogenous population of antibodies in APS
  • Discuss the clinical maternal and fetal significance of HELLP syndrome through the eyes of obstetrics and hematology
  • Explain HELLP syndrome in the context of the genetics of the alternative complement pathway (ACP)
  • Recognize the potential of complement inhibition to reduce early pre-term birth
  • Demonstrate and apply current treatment approaches to complement-mediated diseases for women of childbearing age


The activity begins with breakfast and registration at 7:00 AM, and then is followed by:

  • 7:30 - 7:45 AM -     Welcome/Introduction (Andra H. James, MD, MPH, Gowthami Arepally, MD and Ravindra Sarode, MD)
  • 7:45 - 8:00 AM -     Overview of the Complement Pathway (Sanjay Khandelwal, PhD)
  • 8:00 - 8:15 AM -     Cross-Talk: Thrombosis and the Complement Pathway (Gowthami Arepally, MD)
  • 8:15 - 8:45 AM -     Atypical Hemolytic Uremic Syndrome (aHUS) in Childbearing Age Women (Carla Nester, MD)
  • 8:45 - 9:15 AM -     Management of PNH During Pregnancy and the Postpartum Period (Charles Parker, MD)
  • 9:15 - 9:30 AM -     BREAK
  • 9:30 - 10:00 AM -   Antiphospholipid Antibodies (Ware Branch, MD)
  • 10:00 - 10:30 AM - New Insights into the Pathophysiology of HELLP (Hemolysis, Elevated Liver Enzymes, and Low Platelet Count) Syndrome (Arthur J. Vaught, MD)
  • 10:30 - 10:50 AM - Panel Discussion and Continued Q&A with our Experts (All Faculty, Moderated by Gowthami Arepally, MD)
  • 10:50 - 11:00 AM - Closing Remarks (Gowthami Arepally, MD and Ravindra Sarode, MD)

Activity Director, FWGBD President:

Andra H. James, MD, MPH
Duke University 
Durham, NC

Chair, Moderator/Co-Chair/Faculty in Presentation Order:

Gowthami Arepally, MD
Duke University Medical Center
Durham, NC

Ravindra Sarode, MD
University of Texas Southwestern Medical Center
Dallas, TX

Sanjay Khandelwal, PhD
Duke University
Durham, NC

Carla Nester, MD
University of Iowa Healthcare
Iowa City, IA

Charles Parker, MD
University of Utah School of Medicine
Salt Lake City, UT

Ware Branch, MD
University of Utah, Intermountain Healthcare
Salt Lake City, UT

Arthur J. Vaught, MD
Johns Hopkins School of Medicine
Baltimore, MD 

Joint Accreditation Statement 

This session is jointly provided by the Foundation for Women & Girls with Blood Disorders and Ciné-Med. 

 Cine-med logo        

In support of improving patient care, this activity has been planned and implemented by Ciné-Med and the Foundation for Women & Girls with Blood Disorders. Ciné-Med is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


How to Receive CE Credit


Ciné-Med designates this live activity for a maximum of 3 AMA PRA Category 1Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


This educational activity is approved for 3 contact hours for nurses.

In order to receive CE credit, participants must sign-in at the registration desk, review the CE information (accreditation information, learning objectives, faculty disclosures, etc) and attend the Symposium. At the completion of the Symposium, Ciné-Med will create an online Credit Tracking page specific to the event with evaluation questions. Participants will receive the URL to access the page via the on-site program, a post-activity email, or both. Once the form is completed, participants will receive an email with their certificate of credit. If you have any questions regarding CE credit, please contact the Ciné-Med at

Reserve your space early. Register HERE.